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December 23, 2023 @ 8:00 am - 5:00 pm


A groundbreaking study in nicotine addiction treatment has emerged, challenging conventional methods through the innovative use of Vitamin C and cotinine, a nicotine metabolite. This approach presents a promising alternative to traditional Nicotine Replacement Therapy (NRT), addressing the challenges of nicotine withdrawal. The study explores the conversion of cotinine back to nicotine using Vitamin C, providing a dissolvable film for smokers. This transformative method aims to mitigate withdrawal symptoms effectively.         Key Highlights of the Study:

Utilizing Cotinine:

  • Current NRT relies on additional nicotine, but researchers explore cotinine, an oxidative metabolite of nicotine.
  • Cotinine, formed after smoking, is converted back to nicotine using Ascorbic acid (Vitamin C).
  • A dissolvable film with Vitamin C helps smokers combat nicotine urges without introducing additional toxins.


  • Vitamin C facilitates the conversion of cotinine to nicotine, preventing side effects.
  • The body eliminates toxins without requiring extra nicotine.

Future Considerations and Study Requirements:

  • The converted nicotine may induce Central Nervous System (CNS) effects, aiding in nicotine withdrawal treatment.
  • Researchers emphasize the need for larger studies to validate their findings.

Nicotine Replacement Therapy (NRT):

  • Treatment to help quit smoking by supplying low doses of nicotine.
  • Aims to reduce cravings and ease withdrawal symptoms.
  • Available in various forms: gum, patches, nasal sprays, oral inhalers, and tablets.

Status of Tobacco Consumption in India:

  • Approximately 267 million adults (29% of all adults) in India use tobacco.
  • Smokeless tobacco is prevalent, including khaini, gutkha, betel quid with tobacco, and zarda.
  • Smoking forms include bidi, cigarette, and hookah.
  • Tobacco is a major risk factor for chronic diseases, causing 1.35 million deaths annually.
  • India is the second-largest consumer and producer of tobacco.

Government Initiatives Related to Tobacco Consumption:

Cigarettes and Other Tobacco Products Act (COTPA), 2003:

  • Prohibits advertising and regulates trade, commerce, production, supply, and distribution of tobacco products.

Applies to various tobacco-containing products outlined in the Act’s Schedule.

National Tobacco Control Programme (NTCP):

  • Launched in 2007-08 to create awareness about harmful effects, reduce production, and facilitate WHO Framework Convention of Tobacco Control strategies.
  • Aims to help people quit tobacco use and ensure effective implementation of COTPA 2003.

National Tobacco Quitline Services (NTQLS):

  • Provides telephone-based information, advice, support, and referrals for tobacco cessation.


The study’s innovative approach to nicotine addiction treatment, using Vitamin C and cotinine, marks a significant stride in redefining therapeutic strategies. As India grapples with high tobacco consumption, government initiatives like COTPA and NTCP are crucial. Integrating breakthrough methods, validated through rigorous studies, into existing programs could offer effective solutions for nicotine addiction, contributing to a healthier nation. As research progresses, collaborative efforts between the scientific community and policymakers become pivotal in combating the complex challenge of tobacco use.

Mains Question:

  1. Discuss the significance of the innovative approach involving cotinine and Vitamin C in treating nicotine addiction, as outlined in the study. Evaluate its potential impact on existing Nicotine Replacement Therapy (NRT) methods and the broader implications for public health in India. (150 WORDS)


December 23, 2023
8:00 am - 5:00 pm
Event Category: